[A comparison of the hormonal and etholotropic activity of luliberin and its analogs]. / Sravnenie gormonal'noi i étoltropnoi aktivnosti liuliberina i ego analogov.

The paper is devoted to comparative analysis of the activity of peptides (LH-RH analogs) with relation to their action on ovulation as well as on the learning capabilities and their effect on immobilization stress in rats. The acceleration of learning processes and elimination of immobilization stress were shown to be caused by LH-RH and its analogs, regulating actively ovulation under experimental conditions. The comparative evaluation of their action has shown that LH-RH analogs-antagonists produce a more marked effect on the process of learning and elimination of stress consequences than its analogs-agonists.

[The range of potential practical use for luliberin as a neurotropic peptide]. / Diapazon vozmozhnogo prakticheskogo primeneniia liuliberina kak neirotropnogo peptida.

Some aspects of the effect of LH-RH on behavior reactions and CNS activity were investigated. LH-RH was shown to produce a positive effect on teaching processes in animals, to possess analgesic and antispasmodic activity, and to activate the central nervous system. The adaptogenic properties of LH-RH necessitated a study of its potential to stop dysadaptation.

[Synthesis and pharmacological properties of des-9-glycine analogs of [Orn8]vasopressin]. / Sintez i farmakologicheskie svoistva dez-9-glitsinovykh analogov [Orn8]vazopressina.

Three new analogues of vasopressin, viz. des-Gly9-[Phe2, Orn8]vasopressin, diglycyl-des-Gly9-[Phe2, Orn8]vasopressin, and diglycyl-des-Gly9-[Val4, Orn8]vasopressin, were synthesized to investigate the structure-function relationship. Hormonal (vasopressor, antidiuretic, uterotonic, galactogogic) activities of the new compounds were determined, their effect on elaboration and retention of the active avoidance behaviour in rats was studied.

[Psychotropic properties of corticotropin and its analogs]. / Psikhotropnye svoistva kortikotropina i ego analogov.

The authors presented evidence for the effect of 6 analogues of ACTN4-10 on teaching of albino rats in a labyrinth with negative electrocutaneous reinforcement. Sixteen series of experiments on 192 rats demonstrated a positive effect of corticotropin fragments on memory processes. The activating ACTH fragment effect was shown in recording the background and bioelectrically induced rabbit brain activity in response to a photo-flash in 36 experiments on 18 animals. Three groups of 30 patients with alcohol withdrawal syndrome, posttraumatic craniocerebral effect and schizophrenia received injections of corticotropin as a therapeutic agent. A high efficacy of corticotropin in the treatment of the alcohol withdrawal syndrome and after effect of craniocerebral injury and a low efficacy and sometimes aggravation of symptoms in schizophrenia patients were shown.

[Pathogenesis and treatment of migraine (neuroendocrinologic aspect)]. / K patogenezu i lecheniiu migreni (neiroéndokrinologicheskii aspekt).

In 24 women with simple and ophthalamic migraine the authors employed neuropeptide 8-arginine-vasopressin under control of plasma levels of ACTH and cortisol and rheoencephalographic parameters. The authors observed a marked clinical effect, normalization of hypothalamoadrenal function and improvement in the cerebral hemodynamics.

[Neuropeptides in the treatment of alcoholism and alcoholic psychoses]. / Neiropeptidy v terapii alkogolizma i alkogol'nykh psikhozov.

The intranasal administration of the hypothalamic peptide hormones vasopressin and corticotropin was used in the therapy of alcohol abstinence syndrome, acute and chronic alcoholic psychoses and in the conditioned reflex therapy of alcoholism. The proposed methods of therapy were fairly effective and free of complications and marked side effects.

Comparative activity of memory-modulating neuropeptides before and after electric shock in white rats.

Neuropeptides are shown to exert a powerful influence on mnestic processes. They actively eliminate phenomena of electric-shock amnesia, the strongest agent here being arginine vasopressin, while derivatives of oxytocin, enkephalin, and melanostatin are active to a lesser degree. The selective effect on primary learning (ACTH4-7 and Leu-enkephalin) and on the consolidation and restoration of memory (vasopressin and oxytocin), and the presence of only antiamnestic properties (analog of the melanocyte-inhibiting factor) - all this suggests different mechanisms of action of these agents. Memory modulators act more strongly upon activated systems that are already prepared to receive the signal. A promising object for future study as a therapeutic antiamnestic factor is the long-term memory modulator arginine vasopressin.

[Effect of insulin and its polymeric analogs on learning and memory processes in the rabbit]. / Vliianie insulina i ego polimernykh analogov na protsessy obucheniia i pamiati u krolikov.

The effect of insulin and its seven synthetic derivatives on spontaneous bioelectrical activity of the cerebral cortex of rabbits was described in the paper. The influence of these substances on consolidation of long-term memory of white rats was shown at normal state and during experimental neurosis. Insulin was supposed to influence the higher nervous activity not only through glucose metabolism but also by means of increase of permeability of biological membranes for amino acids.

[Non-classic effects of luliberin confirming the pleiotropy of neuropeptides]. / "Neklassicheskie" éffekty liuliberina, podtverzhdaiushchie mnogoadresnost' neiropeptidov.

The effects of synthetic neuropeptide LH-RH and its analogues were studied in experiments on 174 white male rats. The influence of the substances was shown on instrumental avoidance learning in Y-shaped maze. Convulsive and anticonvulsive effects of the preparations were studied on experimental model of corasol seizures. The analgetic effect of the substances was evaluated by behavioural pain reaction to electrical stimulation of the tail root. Analgetic, anticonvulsive, and psychostimulating LH-RH properties confirm polyfunctionality and "pleiotropy" of neuropeptides as a class of new endogenous informational compounds.